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Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report

Received: 4 October 2016    Accepted: 21 April 2017    Published: 26 September 2017
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Abstract

Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.

Published in International Journal of Neurologic Physical Therapy (Volume 3, Issue 4)
DOI 10.11648/j.ijnpt.20170304.11
Page(s) 25-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Phenytoin Toxicity, Cerebellar Dysfunction, Epilepsy

References
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[3] Benabou R. Carpenter S. Adermann F Dubeau F, Sherwin A. Progressive irreversible ataxia after long term phenytoing therapy. Neurology 1995; 45 (suppl 4): A368.
[4] Meena Gupta et. al persistent cerebellar ataxia with cerebellar cognitive affective syndrome due to acute phenytoin intoxication: A case report, Neurology Asia, 3013: 18 (1): 107-111.
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[8] Nitin Kumar, Annaya Chakraborthy, Anand L Betdur, Phenytoin-Induced Cerebellar atrophy and epileptic boy, In Journal of Pharmacology, 2013: 45 (6): 636-637.
[9] Ahuja SR, Karade S, Kulkarni MV, Cerebellar atrophy in an epileptic child: Is it due to phenytoin? Journal of Postgraduate Medicine, 2000; 46: 278-9.
[10] DP Holschneider, J Yang Y Guo, J-M I Maarek, Reorganization of Functional Brain Maps After exercise Training: Importance of cerebellar- Thalamic- Cortical Pathway, Brain Res. 2007 December 12; 1184: 96-107.
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[14] Matthis Synozik, Winfried Tlg, Motor Training in Degenerative Spinocerebellar Disease: Ataxia-Specific Improvements by Intensive Physiotherapy and Exergames, BioMed Research International, 2014, 10.1155/583507.
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  • APA Style

    Tenzing Norbu Lama, Smita K. C. (2017). Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. International Journal of Neurologic Physical Therapy, 3(4), 25-27. https://doi.org/10.11648/j.ijnpt.20170304.11

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    ACS Style

    Tenzing Norbu Lama; Smita K. C. Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. Int. J. Neurol. Phys. Ther. 2017, 3(4), 25-27. doi: 10.11648/j.ijnpt.20170304.11

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    AMA Style

    Tenzing Norbu Lama, Smita K. C. Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report. Int J Neurol Phys Ther. 2017;3(4):25-27. doi: 10.11648/j.ijnpt.20170304.11

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  • @article{10.11648/j.ijnpt.20170304.11,
      author = {Tenzing Norbu Lama and Smita K. C.},
      title = {Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report},
      journal = {International Journal of Neurologic Physical Therapy},
      volume = {3},
      number = {4},
      pages = {25-27},
      doi = {10.11648/j.ijnpt.20170304.11},
      url = {https://doi.org/10.11648/j.ijnpt.20170304.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnpt.20170304.11},
      abstract = {Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.},
     year = {2017}
    }
    

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    T1  - Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report
    AU  - Tenzing Norbu Lama
    AU  - Smita K. C.
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    T2  - International Journal of Neurologic Physical Therapy
    JF  - International Journal of Neurologic Physical Therapy
    JO  - International Journal of Neurologic Physical Therapy
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    PB  - Science Publishing Group
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    AB  - Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Manual Therapy and Pain Relief Centre, Lalitpur, Nepal

  • School of Medical Sciences, Department of Physiotherapy, Kathmandu University, Dhulikhel, Nepal

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