The Relationship Between Clopidogrel Gene Polymorphism to Progressive Stroke or Recurrence
Yuelian Lian,
Xiufeng Xin
Issue:
Volume 6, Issue 1, June 2020
Pages:
1-6
Received:
15 February 2020
Accepted:
2 March 2020
Published:
10 March 2020
Abstract: Background: Progressive stroke is big problem what's bothering neurophysicians. CYP2C19 gene metabolism test has become more and more popular and even the routine examination of cerebral infarction patients. Objective: To evaluate the correlation of CYP2C19 gene metabolic typing, antiplatelet drug therapy to progressive stroke; to evaluate the relationship between secondary prevention compliance to recurrence of cardiovascular and cerebrovascular events. Method: Through single center and retrospectivly information collected and analyze, collect the information of gene detection of CYP2C19 in patients with acute cerebral infarction admitted within 7 days from 2012 to 2016 and used clopidogrel, antiplatelet drug therapy, past history and others to analyze the related factors to progressive stroke; through regular telephone or outpatient follow-up to evaluate the relationship between secondary prevention compliance to recurrence of cardiovascular and cerebrovascular events. Result: A total of 436 patients were collected. CYP2C19 fast metabolism type (*1/*1) accounted for 39.22%, medium metabolism type (*1/*2 and *1/*3) 50.92%, slow metabolism type 9.86%(*2/*3, *2/*2 and *3/*3). Patients with good secondary prevention compliance had fewer cardiovascular and cerebrovascular recurrence events. There’s no significant correlation between the choice of loading dose of clopidogrel or combination of antiplatelet therapy to progressive stroke and cardiovascular or cerebrovascular events after 3 years of stroke. Conclusion: Limited to retrospective analysis and number of cases in a single center, further research to enlarge the number of centers and cases is needed.
Abstract: Background: Progressive stroke is big problem what's bothering neurophysicians. CYP2C19 gene metabolism test has become more and more popular and even the routine examination of cerebral infarction patients. Objective: To evaluate the correlation of CYP2C19 gene metabolic typing, antiplatelet drug therapy to progressive stroke; to evaluate the rela...
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Analysis of Moral Reasoning of Teachers and the Students with Respect to Kohlberg’s Theory of Moral Development
Muhammad Hafeez,
Fatima Tahira,
Qaisar Abbas Kazmi,
Muhammad Zahid Hussain
Issue:
Volume 6, Issue 1, June 2020
Pages:
7-16
Received:
21 March 2020
Accepted:
9 April 2020
Published:
27 August 2020
Abstract: Moral development of persons is a basic aim of education. According to Islamic teachings, success and failure of a person is judged on moral basis in this world and the hereafter. This study focuses on analysis of moral reasoning of teachers and the students with respect to Kohlberg’s theory of moral development. The target population for this study was teachers and students of secondary schools of district Dera Ghazi Khan. Twenty secondary schools are randomly selected from district Dera Ghazi Khan. Three (03) teachers and ten (10) students from each school are selected using random sampling method. The total sample size will be 60 teachers and 200 students. Data is selected by DIT (defining issue test). The collected data is analyzed through descriptive analysis and chi-square test applied using SPSS. The results reveal that the participants reasoned predominantly at the conventional level of Kohlberg's moral reasoning which found that there is no significant difference between the view of teachers and students towards moral reasoning.
Abstract: Moral development of persons is a basic aim of education. According to Islamic teachings, success and failure of a person is judged on moral basis in this world and the hereafter. This study focuses on analysis of moral reasoning of teachers and the students with respect to Kohlberg’s theory of moral development. The target population for this stud...
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